Chimerism after organ transplantation.

Xenobiotics, chimerism and the induction of tolerance following organ transplantation.

The successful results seen after organ transplantation are largely attributable to the potency and specificity of modern immunosuppressive agents. Although drug-free unresponsiveness to graft alloantigens has not been routinely achieved in clinical practice, recent appreciation of the importance of cell chimerism, which develops after the migration from donor to host of leukocytes contained in...

Bone marrow augmentation for heart, liver, and small bowel transplantation: prolongation of graft survival and incidence of graft-versus-host disease.

THE persistence of donor leukocvtes in recipients after transplantation (chimerism) has been postulated as the basis for graft acceptance. I.: There have been direct efforts to augment chimerism in order to increase the chance of graft acceptance. even though the mechanism of the bidirectional modulation between host and chimeric cells to achieve donor-specific hyporeactivity is not clear. In t...

Chimerism After Whole Organ Transplantation :

Relationship between Molecular Chimerism and Graft Versus Host Disease after Allogenic Hematopoietic Stem Cell Transplantation

Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...

Cell migration and chimerism--a unifying concept in transplantation--with particular reference to HLA matching and tolerance induction.

WE recently reported that the acceptance of wholeorgan transplants connotes (and requires) a special kind of mixed chimerism involving an exchange between organ and recipient oflymphodendritic leukocytes (Fig 1 ).1 The consequence in five of five patients studied 27 to 29V2 years after kidney transplantation from HLA-mismatched donors was the diffuse presence of donor dendritic cells in the lym...